cfd simulations for scale up of wet milling in

Title of Document: CFD SIMULATIONS FOR SCALE UP OF …

Up to now, however, few papers discuss the mean flow and turbulence fields generated by them and their influence on final product quality. In this work, CFD results at different scales are used to aid in the scale up of crystal wet milling processes. CFD simulations were performed to simulate different scale mixers.

CFD SIMULATIONS FOR SCALE UP OF WET MILLING IN …

Up to now, however, few papers discuss the mean flow and turbulence fields generated by them and their influence on final product quality. In this work, CFD results at different scales are used to aid in the scale up of crystal wet milling processes. CFD simulations were performed to simulate different scale mixers.

Why apply DEM simulations in the pharmaceutical ...

5/7/2019· The analysis compared scale-up laws at 150L scale using a fraction of the material that would have been used if scale-up was done through conventional experimentation. Figure 3: Post-processing of a high shear wet granulation case to show velocity, pressure, shear stress, and residence time distribution change with equipment size.

Richard V. Calabrese | AIChE

(424g) CFD Simulations for Scale up of Wet Milling in High Shear Mixers. Meng Yang. Richard V. Calabrese. 2010 Annual Meeting (331a) The Effect of Surfactants On the Breakup of An Axisymmetric Laminar Jet. Justin Walker. Richard V. Calabrese. 2010 Annual Meeting

Mill, material, and process parameters – A mechanistic ...

1. Introduction. Wet stirred media milling is a common process in many industrial areas. In particular, the demand for nano- and submicron particles has increased in pharmaceutical and life science applications,,, and in the ceramics and mining industries,, .These particle systems are extremely diverse, ranging from very soft and temperature sensitive products to very hard and abrasive ...

(424g) CFD Simulations for Scale up of Wet Milling in High ...

(424g) CFD Simulations for Scale up of Wet Milling in High Shear Mixers. Conference ... pilot scale and plant scale flow field and deformation rate phenomena and match these on all scales to extrapolate bench scale data with respect to the number of mill head passes and shear rate history. ... The implication of the results to scale-up of wet ...

High Shear Mixing Research Program - BHR Group

9/23/2015· Mechanisms for and Scale-up of High Shear Wet Milling of Pharmaceutical Ingredients Computational Fluid Dynamics - bench, pilot & plant scales Wet milling of crystals on bench scale – preliminary experiments • Chevron Energy Technology Company (ETC) …

Tablet Press Feed Frames The Influence of Design and ...

Tablet Press Feed Frames: The Influence of Design and Operation On Powder Flow and Tablet Quality ... A Combined Experimental and Computational Approach to the Scale-up of High-Shear Wet Granulation. Pandey, P. / Tao, J. / Gao, ... CFD Simulations for Prediction of Scaling Effects In Pharmaceutical Fluidized Bed Processors At Three Scales.

CFD simulations in Automotive Domain

Application of Numerical Simulations . Automotive. There are wide range of applications of numerical methods such as CFD in automotive domain ranging from system level External and Underhood aerodynamics to brake cooling to the simulation of combustion phenomena inside engine cylinders.

Bench Scale Milling - najamariedomsel.de

Cfd Simulations For Scale Up Of Wet Milling. Bench scale wet milling experiment were performed at 4000 6000 and 8000 rpm using sucrose and mannitol in the Silverson L4R inline mixer. The crystal size decreases with rotation rate at both free pumping conditions and constant flow rate conditions.

Computational Fluid Dynamics Simulations of an In-line ...

Title of Thesis: COMPUTATIONAL FLUID DYNAMICS SIMULATIONS OF AN IN-LINE SLOT AND TOOTH ROTOR-STATOR MIXER Author: I. Ko Master of Science, 2013 Directed by: Professor Richard V. Calabrese Department of Chemical and Biomolecular Engineering Unlike conventional stirred tanks, rotor-stator mixers provide high deformation rates to a relatively limited volume, resulting in a …

Meng Yang - Engineer - Procter & Gamble | LinkedIn

Developed Computational Fluid Dynamics (CFD) simulations method to investigate scale up of wet milling in high shear mixers from laboratory scale to plant scale.

Nanomilling of Drugs for Bioavailability Enhancement: A ...

5/20/2016· Even at lab/small-scale, milling time for wet media milling processes can vary from 0.25 h to 1 day (see Table 2), which largely depends on the specific equipment-media-drug used, overall power density (specific energy consumption), and batch size. In general, wet stirred mills impart higher power density than planetary mills and rotating ball ...

IPPE - Simulation Science

CFD simulations of flows in clean environments (i.e., flows in clean rooms, locks, isolators, decontamination devices) enable an optimal design and can help to solve problems in the operation of these processes. Our group has many years of experience with these simulations and is happy to support industrial customers with their questions.

PROGRAM - Mixing

CFD Simulations for Scale up of Wet Milling in High Shear Mixers Meng Yang, Richard V. Calabrese (speaker), University of Maryland, College Park, USA 8:20 pm CFD Analysis and Testing of Magnetic Capture of Rare Cells from Whole Blood 1Zhixi Qian, 2Paul W. Todd, 1Thomas R. Hanley (speaker), 1Department of Chemical Engineering, Auburn

DEM–CFD simulation of particle comminution in jet-mill ...

The implementation of collision models [42] and of smart numerical solutions to speed up the simulations [43] have been documented, however a self-consistent CFD-DEM description of jet milling …

DEM simulation of bead motion during wet bead …

For wet processes, the DEM simulations are coupled with computational fluid dynamics (CFD) or smoothed particle hydrodynamics (SPH) [40] [41] [42][43]. The quality of the predicted results using ...

Presentations at the 2010 AIChE Annual Meeting

Scale-up Effects On the Growth Kinetics in High-Shear Wet Granulation: a Case Study ... In-Situ Seed Generation with Wet Milling for Pharmaceutical Crystallization ... CFD Simulations of the NETL Chemical Looping Experiment ...

Grinding and Dispersing: Chemical Engineering & …

An approach was derived to simulate a wet mill using a modified contact model in a discrete‐element method. The model was compared with bead‐bead simulations. The calculated bead movement could then be used to compute stress energy distributions. The gained results show that this approach is a possibility to calculate a wet‐operated mill.

Chemical Engineering Archives - Final Year Thesis

1/29/2013· In this work, CFD results at different scales are used to aid in the scale up of crystal wet milling processes. CFD simulations were performed to simulate different scale mixers. In addition, wet milling studies were conducted at the bench scale to complement the CFD results and predict wet milling performance in larger scale mixers.

MEI Blog: Report on Computational Modelling '19

6/18/2019· The micro-scale CFD simulations show that the lubrication force is the most significant of these additional affects, and that the degree of interface mobility has an important influence on the magnitude of the other additional forces. Recommendations for sub-models for use in macro-scale CFD models were discussed.

Organic Process Research & Development | Vol 17, No 10

Model-Based Scale-up and Design Space Determination for a Batch Reactive Distillation with a Dean–Stark Trap. ... Use of Computational Fluid Dynamics for Development and Scale-Up of a Helical Coil Heat Exchanger for Dissolution of a Thermally Labile API ... High-Shear Rotor–Stator Wet Milling for Drug Substances: Expanding Capability with ...

Cfd Modelling Of A Stirred Bead Mill For Fine Grinding ...

cfd simulations for scale up of wet milling in. Meng Yang - Engineer - Procter Gamble LinkedIn. Developed Computational Fluid Dynamics (CFD) simulations method to investigate scale up of wet milling in high shear mixers from laboratory scale to plant scale. read more

Multiscale simulation of fine grinding and dispersing ...

On the meso scale the interaction between an ensemble of interacting particles and the interstitial fluid can be pictured by coupled DEM-CFD simulations in a resolved method. In contrast to the non-resolved method applied for the macro scale, the grid spacing is significantly smaller than the grinding media diameter in this case.

Using Simulation Software to Analyze and Improve …

7/4/2017· Particle simulations are also very useful in assessing the equipment efficiency, especially in cases of changing operational conditions, increasing production, or dealing with unanticipated material properties. Some specifics on how particle simulation software can help engineers analyze and improve mixing equipment are provided below.

Insights - Tridiagonal Solutions

Standalone DEM has been used to model mixing, sieving, milling, tablet coating, hopper discharge, etc. If the fluid effects are important, like in wet granulation, drying, fluidized bed processes, wet milling, etc., then DEM-CFD two way coupling models can be used. Check our brochure on CFD …